Table 4 Clinical features of patients in different groups (EBER cut-off: 50%).

From: Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age

Variable

Number.(%)

All age

P value

Elderly group

P value

Young group

P value

EBV+

EBV-

EBV+

EBV-

EBV+

EBV-

Number. (%)

Number. (%)

Number. (%)

CRP

117

19

98

 

13

63

 

6

35

 

Over ULN

57 (48.7)

15 (78.9)

42 (42.9)

0.004

10 (76.9)

28 (44.4)

0.033

5 (83.3)

14 (66.7)

0.080

Normal

60 (51.3)

4 (21.1)

56 (57.1)

 

3 (23.1)

35 (55.6)

 

1 (16.7)

21 (33.3)

 

β2MG

134

18

116

 

11

75

 

7

41

 

Over ULN

59 (44.0)

14 (77.8)

45 (38.8)

0.002

9 (81.8)

34 (45.3)

0.024

5 (71.4)

11 (26.8)

0.033

Normal

75 (56.0)

4 (22.2)

71 (61.2)

 

2 (18.2)

41 (54.7)

 

2 (28.6)

30 (73.2)

 

TK1

92

14

78

 

8

53

 

6

25

 

Over ULN

28 (30.4)

4 (28.6)

24 (30.8)

1.000

2 (25.0)

15 (28.3)

1.000

2 (33.3)

9 (36.0)

1.000

Normal

64 (69.6)

10 (71.4)

54 (69.2)

 

6 (75.0)

38 (71.7)

 

4 (66.7)

16 (64.0)

 

CA125

108

16

92

 

11

60

 

5

32

 

Over ULN

42 ()

12 (75.0)

30 (32.6)

0.001

7 (63.6)

18 (30.0)

0.043

5 (100.0)

12 (37.5)

0.014

Normal

66 ()

4 (25.0)

62 (67.4)

 

4 (36.4)

42 (70.0)

 

0 (0.0)

20 (62.5)

 

ESR

163

21

142

 

14

88

 

7

54

 

Over ULN

49 (30.1)

18 (85.7)

31 (21.8)

<0.001

13 (92.9)

20 (22.7)

<0.001

5 (71.4)

11 (20.4)

0.011

Normal

114 (69.9)

3 (14.3)

111 (78.2)

 

1 (7.1)

68 (77.3)

 

2 (28.6)

43 (79.6)

 

Ferritin

152

21

131

 

16

84

 

5

47

 

Over ULN

52 (34.2)

14 (66.7)

38 (29.0)

0.001

10 (62.5)

24 (28.6)

0.009

4 (80.0)

14 (29.8)

0.043

Normal

100 (65.8)

7 (33.3)

93 (71.0)

 

6 (37.5)

60 (71.4)

 

1 (20.0)

33 (70.2)

 

LDH

250

25

225

 

18

145

 

7

80

 

Over ULN

114 (45.6)

14 (56.0)

100 (44.4)

0.271

10 (55.5)

64 (44.1)

0.359

4 (57.1)

36 (45.0)

0.698

Normal

136 (54.4)

11 (44.0)

125 (55.6)

 

8 (45.5)

81 (55.9)

 

3 (42.9)

44 (55.0)

 

CK

149

21

128

 

14

72

 

7

56

 

Complex

5 (3.4)

1 (4.8)

4 (3.1)

0.537

1 (7.1)

2 (27.8)

0.417

0 (0.0)

2 (3.6)

1.000

Normal

144 (96.6)

20 (95.2)

124 (96.9)

 

13 (92.9)

70 (97.2)

 

7 (100.0)

54 (96.4)

 

BM

150

22

128

 

15

83

 

7

45

 

Positive

17 (11.3)

4 (18.2)

13 (10.2)

0.279

3 (20.0)

8 (9.6)

0.366

1 (14.3)

5 (11.1)

1.000

Negative

133 (88.7)

18 (81.8)

115 (89.8)

 

12 (80.0)

75 (90.4)

 

6 (85.7)

40 (88.9)

 
  1. Abbreviations: EBV: Epstein-Barr virus; CRP: serum C reactive protein; ULN: upper limit of normal; β2MG: β2 microglobulin; ESR: erythrocyte sedimentation rate; LDH: lactate dehydrogenase; CK: chromosome karyotype; BM: bone marrow.
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