Figure 5 | Scientific Reports

Figure 5

From: Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency

Figure 5

Chelerythrine improved glucose tolerance and insulin sensitivity with reduced adipogenesis activity in db/db mice.

The food intake (a) body weight (b) serum glucose levels (c) serum insulin (d) Hb1Ac (e) and GSP (f) were measured in db/db mice and their littermate controls (white bars or round symbols). db/db mice were i.p. injected with vehicle (HBC, grey bars or diamond symbols), 3 mg/kg rosiglitazone (Rosi, stripped bars or square symbols) or 3 mg/kg chelerythrine (CHE, black bars or triangle symbols) for 14 days. Insulin (1 unit/kg) and glucose (1 g/kg), respectively, were administered by i.p. injected in 6-h-fasted db/db mice or their littermate controls for the GTT (g) and ITT (h). (i,j) The mRNA levels of genes involved in adipogenesis and glucose metabolsim in liver (i) and epididymal fat pads (j) were measured. Error bars represent s.e.m.; *p < 0.05, **p < 0.01, compared with vehicle treated db/db mice.

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