Figure 2
From: Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin
Prediction of tetherin-mediated intrinsic herd immunity.
(A) (left) The distribution of set-point viral load in untreated individuals in the Zambian Transmission Study (black bars). The black curve is the distribution predicted by the structured epidemiological model. (right) The predicted distribution of set-point viral load in untreated individuals in the Zambian Transmission Study, assuming non-functional Vpu (orange bars). The bar at “0” shows the fraction of populations protected from vpu-deficient HIV-1 infection. (B) Simulated spread of wild-type and vpu-deficient HIV-1 among a population of 1 million individuals. The black and orange curves describe the number of individuals infected by wild-type and mutant virus, respectively. (C) Prevalence of wild-type (black curve) and vpu-deficient (orange curve) HIV-1 infection in (B).
