Figure 5 | Scientific Reports

Figure 5

From: Bioresponsive antisense DNA gold nanobeacons as a hybrid in vivo theranostics platform for the inhibition of cancer cells and metastasis

Figure 5

(A) Histological analysis of gastric tumor and lung tissue indicating a reduced vascularization in the primary tumor and a decrease in tumoral clones in lung tissue treated with anti-Kras nanobeacons only. Nonsense nanobeacons group present inflammatory cells accumulation at bronchoalveolar junction and thickened local alveolar walls and high prevalence of tumoral clones (arrows). (B) Representative confocal microscopy images of lung tissue immunostaining, confirming the persistence of gastric cancer metastasis in the lungs. Blue: DAPI nuclear stain; red: Alexa-Fluor®594-labeled anti-human vimentin; green: FITC-labeled anti-human HLA. Scale bars, 20 μm. (C) anti-Kras nanobeacons treatment significantly reduced the number of spontaneous lung metastasis in gastric cancer model (***P < 0.005, n = 6 mice). (D) Kaplan-Meier survival curves for mice treated with nonsense (black) and anti-Kras (red) nanobeacons using Log-Rank test. Data points represent group mean ± SD (n = 6, ***P < 0.005).

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