Figure 1 | Scientific Reports

Figure 1

From: Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations

Figure 1

Treatment with CTLA4 blockade results in dichotomous and symmetric responses in identical tumor-bearing mice.

(a) BALB/c mice were inoculated s.c. with AB1-HA mesothelioma cells on day 0, followed by i.p. injection of 200 μg anti-CTLA4 (n = 18) or PBS on day 6 or 7 (n = 21 mice, pooled data from 2 independent experiments). (b) Bilaterally inoculated AB1-HA tumor-bearing mice were treated with anti-CTLA4 on day 5 or 6 (n = 30 mice, pooled data from 2 independent experiments, colour-coded per mouse). Asymmetric responding tumours are marked with an asterisk. (c) Graphic representation of the experimental approach.

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