Table 1 Physicochemical characteristic of RGD10-10R/siRNA complexes with various molar ratios.
From: Systemic Administration of siRNA via cRGD-containing Peptide
Formulation | Size (nm) | PDI | ZP (mV) | Mob (μmcm/Vs) | Cond (mS/cm) |
|---|---|---|---|---|---|
RGD10-10R/siRNA 20:1 | 152.02 ± 77.27 | 0.115 ± 0.068 | 5.20 ± 1.49 | 0.408 ± 0.117 | 0.0546 ± 0.0176 |
RGD10-10R/siRNA 50:1 | 116.86 ± 61.90 | 0.150 ± 0.083 | 21.40 ± 7.92 | 1.677 ± 0.621 | 0.0294 ± 0.0033 |
RGD10-10R/siRNA 100:1 | 144.51 ± 39.82 | 0.172 ± 0.034 | 20.08 ± 2.69 | 1.575 ± 0.211 | 0.0465 ± 0.0063 |
Lipofectamine 2000/siRNA | 140.5 ± 15.27 | 0.261 ± 0.040 | 24.40 ± 7.01 | 1.913 ± 0.548 | 0.0498 ± 0.0271 |
Naked siRNA | ND | ND | −8.38 ± 2.54 | −0.657 ± 0.199 | 0.0418 ± 0.0232 |
