Figure 6
From: Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer
miR-182 promotes tumor growth by targeting HIF1α pathway.
(a–c) PC-3-MDH1 or PC-3-MDH1-182 cells were injected subcutaneously into nude mice (n = 6). The overexpression of miR-182 in xenografts was confirmed by RT-PCR analysis (c). Tumors were photographed (a) and weighed (b) as indicated. (d) Western blot analysis of HIF1α protein levels in PC-3-MDH1 and PC-3-MDH1-182 xenografts. (e) PHD2 and FIH1 mRNA levels in xenografts were analyzed by RT-PCR. Data are mean ± SEM. **p < 0.01. Full-length blots are presented in Supplementary Fig. S6.
