Figure 3 | Scientific Reports

Figure 3

From: Activation of TRESK channels by the inflammatory mediator lysophosphatidic acid balances nociceptive signalling

Figure 3

TRPV1 and TRESK are simultaneously activated by LPA.

(A) LPA augmented capsaicin activated currents in TRPV1 injected oocytes. (B) TRPV1 and TRESK co-expressing oocytes displayed an augmented inward and outward current upon application of LPA. (C) Pulse protocol to the respective reversal potentials demonstrated time-locked co-activation of TRESK and TRPV1 with LPA expressed in the same oocyte. (D) LPA-induced augmentation of TRESK and TRPV1 currents were depicted on a larger time scale. Note the fast deactivation of TRPV1 currents upon sole activation with LPA.

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