Figure 5
LPA receptors activate IKSO currents in DRG neurons.
(A) Patch-clamp recordings from TRESK[wt] neurons displayed an increase in current amplitude of IKSO standing-outward currents after application of 10 μM LPA (upper panel, black trace) reversed by lamotrigine (upper panel, grey trace). In neurons from TRESK[ko] mice LPA application had no effect on IKSO (lower panel). Bar graph summarises data from left panel and from neurons 5 days in culture as indicated. (B) Recordings from capsaicin positive TRESK[wt] neurons display augmentation of either outward and inward currents upon LPA application, respectively whereas TRESK[ko] neurons display only augmentation of inward currents.
