Figure 6

Effect of eritoran on behavior of nociceptive response at 1 day post-pulp exposure.

Results from the open-field test and HWTs test in different groups: compared to the other groups, the nociceptive response was significantly increased in left TG in AP-1 group, which was rescued by eritoran or ibuprofen administration. After eritoran or ibuprofen administration, the activity time was increased significantly while the grooming time was down-regulated in the AP-1 + E group compared with the AP-1 group. The rearing times were also increased in the AP-1 + E and AP-1 + I group compared with the AP-1 group. The level of the HWTs to mechanical and heat stimulation of the tongue ipsilateral to the injured pulp were significantly higher in the AP-1 + E/AP-1 + I group than AP-1 group, while it showed no difference between the AP-1 and AP-1 + V group. ^**P < 0.01 vs. SHAM; ^##P < 0.01 vs. AP-1; n = 8 for each group.