Figure 1
From: Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein
Bioinformatics characterization of human pVHL N-terminus.
(A) Roman numerals are used for repeats, while mutations promoting cancer insurgence are presented with red dots. Blue boxes are used for predicted USP7 binding sites. (B) Schematic representation of pVHL isoforms. The N-terminal tail is presented in light blue, while green and purple are used for the β- and α-domain forming pVHL, respectively. A multiple sequence alignment of pVHL is presented in Figure S2. (C) Simplification of pVHL-N sequences found in different animals. Repeat units were only found in mammals, with their number varying among species.
