Figure 2
From: Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein
Top ten ab initio models of pVHL-N.
(A) The ten best models of the pVHL30 N-terminal tail, ordered by relative frequency. The models were extracted by clustering 25,000 decoys. Red spheres represent the position of mutations found in VHL patients. (B) pVHL-N secondary structure propensities from CSpritz23 are shown. Intrinsic disorder predictions for pVHL-N from MobiDB22, with the orange line representing a consensus of different methods (i.e. full disorder). pVHL-N secondary structures, calculated starting from the three-dimensional models, are shown together with the sequence. Red boxes are used to highlight the P25L, S38P, E52K mutation positions. For each line, the percentage of disordered residues is presented on the left side.
