Table 1 Antisense CPMOs and scrambled CPMO sequences (25-mer).

From: Antiviral Phosphorodiamidate Morpholino Oligomers are Protective against Chikungunya Virus Infection on Cell-based and Murine Models

Construct

Sequence (5’ – 3’)a

Sequence Homology (%)b

Target site in CHIKV genome

CPMO1/CPMO1v

TGGGTTATTAATCTCTTGCTTTGCA

56.1

26–50

sCPMO1/sCPMO1v

GTGTATTGATTATCCCTTTCGATGT

 

—

CPMO2

TTGGGATGAACTCCATTGTAGCTGA

62.1

7531–7570

sCPMO2

GTTGAGTGAACTACCTGTTGACGTA

 

—

  1. aThe mispaired bases of the scrambled CPMO (sCPMO) sequences relative to CPMO are presented in bold and underlined.
  2. bCPMO1 and CPMO2 sequence are 100% conserved in query coverage and identity to 56.1% and 62.1% of all published CHIKV strains in NCBI database.
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