Table 2 Characteristics of renal transplant recipients with and without disease progression of kidney allograft.

From: Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection

Characteristic	Non-progressor	Progressor	P Value
Characteristic	(n = 65)	(n = 31)	P Value
Demographics
Age at biopsy (yr)	49.7 ± 11.3	50.4 ± 13.5	0.784^a
Men (n [%])	34 (52.3)	13 (41.9)	0.342^b
Diabetes mellitus (n [%])	22 (33.8)	7 (22.6)	0.261^b
Systolic BP (mmHg)	137.2 ± 21.9	137.0 ± 16.2	0.967^a
Body mass index, (kg/m²)	23.8 ± 3.7	23.2 ± 4.9	0.443^a
Timing of the biopsies, (months; median [interquartile range])	64.0 (2.6–157.6)	86.4 (23.2–137.5)	0.689^d
Total HLA mismatches	3.1 ± 1.4	2.7 ± 1.2	0.138^a
PRA class I ≥ 10% (n [%])	9 (13.8)	3 (9.7)	0.746^c
PRA class II ≥ 10% (n [%])	10 (15.4)	2 (6.5)	0.326^c
Previous acute rejection (n [%])	14 (21.5)	12 (38.7)	0.077^b
Recipient risk score (A–D, 4 grades)	1.5 ± 0.6	1.6 ± 0.7	0.761^a
Donor age (yr)	31.6 ± 10.8	30.3 ± 8.9	0.564^a
Live donor (n [%])	19 (29.2)	9 (29.0)	0.984^b
Cold ischemia time (hours)	8.7 ± 4.5	8.3 ± 4.0	0.691^a
Donor risk score (0–39 points)	7.8 ± 6.2	7.6 ± 5.9	0.897^a
High DcR3 expression (n [%])	22 (33.8)	22 (71.0)	0.001^b
Laboratory data
Serum albumin (g/dL)	3.8 ± 0.5	3.4 ± 0.6	0.001^a
Total cholesterol (mg/dL)	198.5 ± 43.8	195.7 ± 64.9	0.808^a
Urine protein (g/24 h; median [interquartile range])	0.46 (0.17–0.93)	1.49 (0.34–3.40)	0.004^d
eGFR, MDRD (ml/min/1.73 m²)	34.0 ± 15.6	20.9 ± 10.8	<0.001^a
Histopathology of renal allograft biopsy
Acute rejection (n [%])	36 (55.4)	17 (54.8)	0.960^b
TCMR	24 (36.9)	12 (38.7)
ABMR	8 (12.3)	2 (6.4)
Mixed TCMR and ABMR	4 (6.2)	3 (9.7)
Borderline rejection (n [%])	17 (26.1)	7 (22.6)	0.705^b
CAMR and Transplant glomerulopathy (n [%])	12 (18.5)	7 (22.6)	0.646^b
IF/TA (n [%])			0.006^b
0	20 (30.8)	5 (16.1)
<25%	35 (53.8)	11 (35.5)
26–50%	6 (9.2)	11 (35.5)
>50%	4 (6.2)	4 (12.9)
CADI scores (0–18 points)	5.3 ± 3.3	7.3 ± 3.3	0.008^a
Banff tubulitis score	1.2 ± 1.0	1.5 ± 1.0	0.167^a
Banff interstitial inflammation score	1.5 ± 0.9	1.8 ± 1.0	0.173^a
Peritubular capillaritis score (median [interquartile range])^e	0.0 (0.0–1.0)	0.0 (0.0–1.0)	0.225^d
Glomerulitis score (median [interquartile range])	0.0 (0.0–1.0)	0.0 (0.0–1.0)	0.605^d
C4d staining by IHC (C4d0 – C4d3) (median [interquartile range])^f	0.0 (0.0–2.0)	0.0 (0.0–2.0)	0.561^d
Intimal or transmural arteritis (median [min–max])	0.0 (0.0–2.0)	0.0 (0.0–3.0)	0.055^d
Medications
ACEI/ARB (n [%])	31 (47.7)	12 (38.7)	0.408^b
Immunosuppression (n [%])			0.196^b
CNI + MMF-based	57 (87.7)	24 (77.4)
CNI + mTOR inhibitor-based	3 (4.6)	2 (6.5)
mTOR inhibitor-based	0 (0.0)	2 (6.5)
Other	5 (7.7)	3 (9.5)

Comparison by
^aindependent-samples t test.
^bChi-square test.
^cFisher’s Exact test, and.
^dMann-Whitney test with IQR, interquartile range. C4d, Complement component 4d.
^ePeritubular capillaritis score (reference: Gibson, I. W. et al. Peritubular capillaritis in renal allografts: prevalence, scoring system, reproducibility and clinicopathological correlates. Am. J. Transplant. 8, 819–825 (2008)).
^fC4d0 (negative); C4d1 (ATN-like minimal inflammation); C4d2 (Capillary and or glomerular inflammation (ptc/g >0) and/or thrombosis); C4d3 (Arterial – v3). (reference: Sis, B. et al. Banff ′09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am. J. Transplant. 10, 464–471 (2010)).

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Table 2 Characteristics of renal transplant recipients with and without disease progression of kidney allograft.

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