Figure 2
From: TRPA1 mediates the hypothermic action of acetaminophen
APAP induces hypothermia independently of TRPV1.
(A) Oral administration of the TRPV1 antagonist BCTP (30 mg/kg) elicited hyperthermia in C57BL/6J mice (n = 6), but did not inhibit the hypothermia produced by a subsequent dose of APAP (300 mg/kg). (B) APAP (300 mg/kg) evoked identical hypothermia in Trpv1+/+ and Trpv1−/− mice (n = 6). Data are mean ± sem; *p < 0.05, **p < 0.01, ***p < 0.001 compared to vehicle (ANOVA followed by Tukey’s HSD test).
