Figure 3
From: TRPA1 mediates the hypothermic action of acetaminophen
Antipyretic and hypothermic activity of APAP in yeast induced hyperthermia.
Administration of yeast (2 g/kg) produced hyperthermia in wildtype, Trpv1−/− and Trpa1−/− mice. (A) APAP (300 mg/kg) produced hypothermia in both hyperthermic Trpv1+/+ and Trpv1−/− mice (n = 8). (B) APAP produced hypothermia in Trpa1+/+ mice, but acted as an antipyretic, restoring normal, pre-yeast injection, temperature in Trpa1−/− mice. Dashed lines indicate pre-yeast body temperature. Data are mean ± sem; *p < 0.05, **p < 0.01, ***p < 0.001 compared to pre-yeast injection and ††p < 0.01, †††p < 0.001 compared to Trpa1+/+ (ANOVA followed by Tukey’s HSD test). For clarity, some symbols indicating statistical significance have been omitted from (B).
