Table 1 Number and degree of fusion after different treatments.

From: IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion

DOF a

Number of palatal shelves at different position

24hrs after infection (n=15)

48hrs after infection (n=8)

sh Luc

sh Irf6

TGFβ3

shIrf6+TGFβ3

sh Luc

sh Irf6

TGFβ3

shIrf6+TGFβ3

Anterior

 0–25%

15

15

0

12

0

0

0

0

 25–50%

0

0

0

3

0

0

0

0

 50–75%

0

0

2

0

0

0

0

0

 75–100%

0

0

13

0

8

8

8

8

Middle

 0–25%

13

13

0

12

0

0

0

0

 25–50%

2

2

0

3

0

0

0

0

 50–75%

0

0

2

0

0

0

0

1

 75–100%

0

0

13

0

8

8

8

7

Posterior

 0–25%

13

15

0

13

0

0

0

0

 25–50%

2

0

0

1

0

0

0

0

 50–75%

0

0

4

1

0

0

0

0

 75–100%

0

0

11

0

8

8

8

8

Average of DOF

9.3 ± 8.1%

9.0 ± 7.3%

84.9 ± 9.8%

16.3 ± 10.2%*

90.4 ± 5.3%

89.2 ± 5.0%

91 ± 5.2%

88.8 ± 5.2%

  1. aDOF, Degree of fusion.
  2. *Significant difference between TGFβ3 and shIrf6 + TGFβ3 at 24 hrs after infection was analyzed by t-test (p < 0.001).