Table 2 Univariate and multivariate analyses of parameters associated with disease-free survival (DFS) of all CRC patientsa.

From: Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma

Characteristic

Univariate Analysis

Multivariate Analysis

HR1 (95% CI2)

P-value

HR (95% CI)

P-valueb

Tianjin Training and Internal Validation Cohort

 Age (≥65/<65)

1.11(0.48-2.55)

0.81

1.39(0.54-3.56)

0.49

 Gender (male/female)

0.77 (0.36-1.68)

0.518

0.80 (0.33-1.92)

0.62

 Stage (III/II)

3.54 (1.75-7.81)

0.001

4.54 (1.93-10.6)

0.001

 Histology (high/low)

3.99 (0.88-5.88)

0.072

3.56 (1.27-10.1)

0.017

 Location (colon/rectum)

1.06 (0.49-2.30)

0.873

1.11 (0.48-2.54)

0.79

 miR-145 (low/high)

0.68 (0.30-1.53)

0.35

0.67 (0.27-1.68)

0.39

 miR-17-3p (low/high)

3.72 (1.61-8.60)

0.002

3.74 (1.34-10.4)

0.012

 miR-106a (low/high)

4.31 (1.02,18.27)

0.03

3.34 (1.29-8.62)

0.013

Xiangya Independent Validation Cohort

 Age (≥65/<65)

0.72 (0.25-2.11)

0.551

1.36 (0.42-1.91)

0.61

 Gender (male/female)

0.64 (0.25-1.60)

0.336

2.17 (0.79-5.95)

0.13

 Stage (III/II)

3.36 (1.39-8.10)

0.007

5.12 (1.83-14.2)

0.002

 Histology (high/low)

0.86 (0.39-1.92)

0.718

1.24 (0.50-3.05)

0.64

 Location (colon/rectum)

1.13 (0.50-2.55)

0.764

2.39 (0.90-6.39)

0.08

 miR-145 (low/high)

1.42 (0.64-3.17)

0.39

0.77 (0.29-1.98)

0.58

 miR-17-3p (low/high)

3.09 (1.33-7.24)

0.009

3.74 (1.34-10.4)

0.011

 miR-106a (low/high)

2.61 (1.14-5.98)

0.023

3.34 (1.28-8.63)

0.01

All recruited CRC patients

 Age (≥65/<65)

1.02 (0.99-1.04)

0.142

1.05 (0.99-1.11)

0.09

 Gender (male/female)

0.64 (0.25-1.60)

0.336

1.85 (0.48-9.43)

0.54

 Stage (III/II)

1.68 (1.16-2.44)

0.006

4.13 (1.66-10.2)

0.002

 Histology (high/low)

4.29 (0.95,19.8)

0.059

1.62 (0.71-3.12)

0.098

 Location (colon/rectum)

0.87 (0.44-2.01)

0.874

1.47 (0.62-3.44)

0.38

 miR-145 (low/high)

0.78 (0.46-1.35)

0.382

0.61 (0.26-1.37)

0.228

 miR-17-3p (low/high)

2.72 (1.58-4.69)

<0.0001

2.24 (1.28-3.92)

0.035

 miR-106a (low/high)

2.81 (1.64-4.80)

<0.0001

3.02 (1.36-6.73)

0.007

  1. aData are normalized to let-7d/g/i and presented as the mean ± SEM.
  2. bMann-Whitney unpaired test for rank sum.
Back to article page