Table 1 Quantification of periportal and lobular fibrosis.

From: Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

 

periportal positive area (%)

lobular positive area (‰)

wt

1.433 ± 0.697

0.17 ± 0.08

ApoE−/−

1.728 ± 0.306

0.12 ± 0.09

wt + WD

1.812 ± 1.138

0.16 ± 0.02

ApoE−/− + WD

6.718 ± 3.584bb,cc

0.99 ± 0.11

wt + MCD

5.804 ± 1.967a,c

0.59 ± 0.06

ApoE−/− + MCD

4.827 ± 1.533b,c

0.93 ± 0.10

  1. Quantification of Sirius-red positive stained area, as a marker of hepatic fibrosis, in periportal and lobular areas. ApoE−/− mice fed with Western diet (WD) and mice fed methionine and choline deficient (MCD) diet showed significantly increased periportal fibrosis compared to mice fed normal chow and to wildtype (wt) mice fed with WD. Additionally, in mice with increased periportal fibrosis there is also a trend towards increased lobular fibrosis. Data are presented as mean ± standard deviation. p < 0.05 was considered significant. a = p < 0.05 vs. wt, b = p < 0.05 vs. ApoE−/−, bb = p < 0.01 vs. ApoE−/−, c = p < 0.05 vs wt + WD, cc = p < 0.01 vs. wt + WD.
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