Figure 2 | Scientific Reports

Figure 2

From: A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71

Figure 2

Kinetics of anti-epitope antibody responses.

Groups of five mice were immunized with 0.625, 1.25, 10 and 100 μg/dose i.p. at weeks 0, 2 and 4 with HBc-E1/2, HBc-E1, HBc-E2 or HBc(aa1-149) as described in the Materials and Methods. Sera were collected at 0, 2, 4, 6, 8, 10 and 12 for the serological tests and analyzed by ELISA to measure the epitope-specific antibody response, the VP1(aa208-222)-specific antibody response (A,C,E,G) and the VP2(aa141-155)-specific antibody response (B,D,F,H). All serum samples were prepared using 10-fold dilution series and the first dilution was 100-fold. Each point represents the mean reciprocal log10 endpoint titers and standard error.

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