Figure 6 | Scientific Reports

Figure 6

From: A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71

Figure 6

Sequence alignment of the cross-neutralizing epitope of VP1(aa208-222) and VP2(aa141-155) from NCBI database.

(A) The quality of conservation of epitope sequence alignment and Epitopes sequence logo. The sequence logo was created using Weblogo (http://weblogo.berkeley.edu/logo.cgi). Bits represent the relative frequency of amino acids. (B) Comparison of the cross-neutralizing epitope of VP1 (aa208-222) and VP2 (aa141-155) between EV71 and CA16 based on molecular modeling of the mature EV71 virion structure (PDB: 3VBS). The cross-neutralizing epitope of VP2 is shown in yellows (EV71) and salmon (CA16) on the canyon region, together with the GH loop of VP1, which is in cyan (EV71) and magentas (CA16). The amino acid sequence of the EV71-VP1 GH loop differed from that of CA16 at position K215L, E217A and K218N (A,B). Stereo pictures showing the VP1 and VP2-epitope between EV71 and CA16 (C). All models were prepared using PyMOL (DeLano Scientific).

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