Figure 5
From: Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Stability of MTAbl peptides in human serum.
Time course of the percentage of remaining peptide when incubated in 100% human serum at 37 °C for up to 24 h. The percentage of remaining MTAbl peptides was compared to that of MCoTI-II at 24 h time point using one-way ANOVA. MTAbl09 and MTAbl13 are significantly more stable than MCoTI-II (*p < 0.05 and ***p < 0.001, respectively) after being incubated in human serum for 24 h. Results are the mean ± SEM from three replicates.
