Figure 2 | Scientific Reports

Figure 2

From: Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides

Figure 2

Tunable control of SERCA function using ssDNA of different lengths.

Coupled enzyme assays in DOPC:DOPE lipid vesicles. (a) SERCA activity normalized as a function of Ca2+ concentration. Black is SERCA alone, brown is SERCA and PLN; other colors represent addition of different lengths of ssDNA. (b) pKCa values for the different ssDNA lengths derived from the pCa values at half maximum activity of SERCA. (c) Effects of ssDNA on pig cardiac SR preparations.

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