Figure 5

TLR2 induced radio-protection via Myd88 C57BL/10 mice (20 g in weight, n = 20 per group) were treated with Pam₃CSK₄ (50 ng/ml) and then 24 h later exposed to 7.5, 8.5 and 9.5 Gy TBI as indicated, while control mice received PBS.

Survival was recorded (A). Linear regression analysis of the survival rate for mice treated with Pam₃CSK₄. The equation and the correlation coefficient for the line are given (B). Pam₃CSK₄ protects C57BL/10 mice from radiation injury. Survival was recorded (C). Myd88^−/− and WT mice were exposed to 0 and 6.5 IR and the survival was recorded. All data are expressed as the mean ± s.d. of three separate experiments. *P < 0.05.