Figure 3 | Scientific Reports

Figure 3

From: The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction

Figure 3

Effects of TBHQ on TAC-induced myocyte hypertrophy.

(A) Hematoxylin and eosin stained sections of left ventricular myocardium (bar = 20 μm). All sections were obtained at the same short axis plane as indicated by the insert; the arrow indicated the papillary muscle. (B) Mean cross sectional areas of muscle fibers (n = 5 animals). (C) Changes in heart weight (HW) to body weight (BW) ratio, HW to tibia length (TL) ratio and echo-derived LV mass to TL ratio, n = 5 (Sham), 12 (TAC) and 12 (TAC + TBHQ). (D) Real-time PCR results showing the expression levels of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), α-myosin heavy chain (MHC) and sarcoplasmic reticulum Ca2+ ATPase-2a (SERCA2a) in the heart (n = 6 each). *P < 0.05, one-way ANOVA. NS, no significance.

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