Figure 7 | Scientific Reports

Figure 7

From: The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction

Figure 7

TBHQ activated the Akt pathway in the heart in vivo. (A) Western blot and quantitative densitometry data showing the levels of phosphorylated and total Akt, Bad and ERK1/2 in LV (n = 6). (B) Akt kinase activity measured in the myocardium (n = 6). (C) Western blots showing the effect of TBHQ on phosphorylation of glycogen synthase kinase-3β (GSK-3β) and mammalian target of rapamycin (mTOR). (D) Western blots showing the effects of TBHQ on phosphorylation of Akt1 and Akt2 in the myocardium. *P < 0.05, one-way ANOVA.

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