Table 4 Diagnostic performance of MMP-9 and FIT for the detection of advanced neoplasia and advanced adenomas.

From: Serum matrix metalloproteinase-9 in colorectal cancer family-risk population screening

Biomarker

Advanced neoplasia

Advanced adenomas

Cut-off

Sensitivity (%)

Specificity (%)

Cut-off

Sensitivity (%)

Specificity (%)

MMP-9

0.19

19.30

90

0.18

22.64

90

 

0.24

8.77

95

0.23

9.43

95

FIT

0.17

52.63

90

0.16

47.17

90

 

0.24

45.61

95

0.22

43.40

95

  1. For MMP-9 (log10MMP-9) and FIT [log10(FIT + 2)] the confounders gender and age were included in the regression model to assess the diagnostic performance. The cut-offs are based on the regression model of each marker. FIT: Faecal immunochemical test.
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