Table 2 Reactome pathways identified by ESEA with FDR < 0.05 in the type 2 diabetes dataset.
From: ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis
Pathway | Size of edge | NEES | FDR | Character |
|---|---|---|---|---|
Downregulation of ERBB2-ERBB3 signaling | 31 | −2.11 | <0.001 | LoC |
Amino acid and oligopeptide SLC transporters | 131 | −1.73 | <0.001 | LoC |
Chaperonin-mediated protein folding | 152 | −1.64 | <0.001 | LoC |
Protein folding | 161 | −1.59 | <0.001 | LoC |
Peptide ligand-binding receptors | 79 | 1.57 | <0.001 | GoC |
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7-8 or 9 activation | 227 | 1.42 | <0.001 | GoC |
Nucleosome assembly | 524 | 1.31 | <0.001 | GoC |
