Figure 5
From: Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma
miR-181b overexpression suppressed tumor growth in vivo.
(A) Luminescence imaging was performed on miR-181b-treated LN229 tumors and scramble-treated controls. miR-181b mimic-treated cells displayed a marked reduction in tumor size. (B) Kaplan-Meier survival curves indicating that mice transfected with miR-181b showed a significantly better outcome than the miR-NC-treated group (p = 0.0138). (C) Real-time PCR revealed that miR-181b expression in the miR-181b-treated group was higher than that in the scramble-treated group. (D) Immunohistochemistry for Ki-67, KPNA4, E-cadherin, N-cadherin, Vimentin and MMP-9 was performed on orthotopic tumor sections. The error bars represent the means ± SD for three independent experiments. *p < 0.05.
