Table 1 Characteristics of study cohorts.

From: Elevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk

Trait

Cohort 1

Cohort 2

Total

Female

Male

P value**

Total

Female

Male

P value**

n

1813

1165

648

 

1642

1042

600

 

Age, year

62.12 (9.71)

61.37 (9.64)

63.48 (9.71)

<0.0001

60.72 (8.78)

60.00 (8.75)

61.98 (8.71)

<0.0001

BMI, kg/m2

24.76 (3.36)

24.76 (3.41)

24.77 (3.26)

0.47

24.28 (3.17)

24.37 (3.26)

24.13 (3.01)

0.09

Waist Circumference, cm

85.47 (10.40)

83.68 (10.67)

88.67 (9.05)

<0.0001

81.18 (8.69)

80.27 (8.82)

82.78 (8.21)

<0.0001

ALT, IU/L*

12 (10)

12 (10)

12 (10.5)

0.53

14 (9)

13 (9)

14 (10)

<0.0001

AST, IU/L*

25 (11)

25 (11)

25 (10)

0.86

14 (5)

14 (6)

14 (6)

0.0082

GGT, IU/L*

20 (16)

18 (16)

22.5 (16)

<0.0001

18 (15)

16 (13)

23 (21)

<0.0001

IBIL, μmol/L

4.42 (2.26)

4.33 (2.18)

4.58 (2.37)

0.06

4.79 (2.00)

4.57 (1.87)

5.17 (2.14)

<0.0001

DBIL, μmol/L

2.74 (1.31)

2.54 (1.20)

3.08 (1.43)

<0.0001

3.30 (1.32)

3.09 (1.24)

3.67 (1.37)

<0.0001

TBIL, μmol/L

6.98 (3.23)

6.67 (3.06)

7.53 (3.48)

<0.0001

8.09 (3.09)

7.66 (2.86)

8.83 (3.32)

<0.0001

Hepcidin, ng/mL*

25.62 (19.31)

25.33 (18.56)

26.13 (20.15)

0.15

29.94 (25.12)

30.89 (26.03)

29.07 (22.39)

0.01

Ferritin, ng/mL*

245.52 (206.67)

220.66 (184.79)

295.19 (226.24)

<0.0001

195.45 (185.81)

168.22 (164.09)

253.53 (212.68)

<0.0001

Hemoglobin, g/dL

12.75 (1.71)

12.31 (1.45)

13.55 (1.86)

<0.0001

–

–

–

–

CRP, mg/L*

1.23 (1.98)

1.23 (1.98)

1.22 (1.97)

0.83

–

–

–

–

Diabetic status, yes, n, %

955 (52.68)

554 (47.55)

401 (61.88)

<0.0001

160 (9.74)

89 (5.42)

71 (4.32)

0.04

Smoking

 No smoking, n, %

989 (54.55)

732 (62.83)

257 (39.66)

<0.0001

–

–

–

–

 Passive smoking, n, %

490 (27.03)

407 (34.94)

83 (12.81)

<0.0001

–

–

–

–

 Quitted, n, %

84 (4.63)

4 (0.34)

80 (12.35)

<0.0001

–

–

–

–

 Smoking, n, %

243 (13.40)

16 (1.37)

227 (35.03)

<0.0001

–

–

–

–

Drinking

 No drinking, n, %

1533 (84.56)

1122 (96.31)

411 (63.43)

<0.0001

–

–

–

–

 Quitted, n, %

38 (2.10)

6 (0.52)

32 (4.94)

<0.0001

–

–

–

–

 Drinking, n, %

234 (12.91)

31 (2.66)

203 (31.33)

<0.0001

–

–

–

–

  1. ALT, alanine transaminase; AST, aspartate transaminase; GGT, gamma-glutamyltransferase; CRP, C-reactive protein; DBIL, direct bilirubin; IBIL, indirect bilirubin; TBIL, total bilirubin. Hepcidin (ng/mL) indicates serum hepcidin concentration. Ferritin (ng/mL) indicates serum ferritin.
  2. Data are baseline data and shown as mean (SD).
  3. *Data are shown as median (interquartile range).
  4. **The comparison results between females and males.
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