Figure 5 | Scientific Reports

Figure 5

From: Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning

Figure 5

Application of CRANAD-29 for monitoring the browning of sWAT.

(a) Representative NIR images of a control mouse (left) and a mouse after 12-day CL 316,243 treatment (right) at 4 hours post CRANAD-29 injection. (b) Quantitative analysis of the fluorescence signals at 1, 2 and 4 hours post CRANAD-29 injection (Note that different ROI sizes were used for sWAT in Fig. 5 and iBAT in Fig. 4). (c) UCP-1 expression in sWATs of CL 316,243 treated mice and control mice. (d) H&E staining of sWAT slices of a CL 316,243-treated mouse (right) and a control mouse (left). Black arrows indicated the areas containing multilocular fat cells. Top row: low resolution (10 x), scale bar: 200 micron, bottom row: high resolution (40 x), scale bar: 100 micron.

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