Table 1 Results of meta-analysis on CD44 expression.
From: Prognostic value of CD44 expression in renal cell carcinoma: a systematic review and meta-analysis
Clinical Stage (I + II vs. III + IV) | Recurrence (positive vs. negative) | MVI (positive vs. negative) | Furhman Grade (grade I + II vs. grade III + IV) | 5-Overall Survival (survive vs. death) | 5-Disease Specific Survival (survive vs. death) | 5-Disease Free Survival (survive vs. death) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | RR(95%CI) | N | RR(95%CI) | N | RR(95%CI) | N | RR(95%CI) | N | RR(95%CI) | N | RR(95%CI) | N | RR(95%CI) | |
Over all | 7 | 0.74(0.63, 1.04) | 3 | 7.42(3.75, 14.70) | 2 | 3.63(1.97, 6.71) | 11 | 0.61(0.48, 0.77) | 9 | 0.68(0.60, 0.77) | 4 | 0.46(0.27, 0.80) | 6 | 0.63(0.43, 0.93) |
Geographic area | ||||||||||||||
1. Asian | 2 | 0.63(0.32, 1.22) | NA | NA | NA | NA | 4 | 0.47(0.31, 0.71) | 4 | 0.60(0.49, 0.75) | 1 | 0.58(0.39, 0.89) | 3 | 0.55(0.22, 1.40) |
2. Non-Asian | 5 | 0.79(0.52, 1.21) | NA | NA | NA | NA | 7 | 0.69(0.53, 0.90) | 5 | 0.73(0.63, 0.86) | 3 | 0.39(0.16, 0.92) | 3 | 0.71(0.47, 1.08) |
Staining pattern | ||||||||||||||
1. membrane | 3 | 0.48(0.29, 0.82) | NA | NA | NA | NA | 4 | 0.52(0.23, 1.15) | 1 | 0.54(0.36, 0.80) | NA | NA | 2 | 0.55(0.12, 2.42) |
2. cytoplasm | NA | NA | NA | NA | NA | NA | 1 | 1.00(0.59, 1.70) | NA | NA | NA | NA | ||
3. membrane and cytoplasm | 4 | 0.86(0.61, 1.22) | NA | NA | NA | NA | 7 | 0.63(0.49, 0.82) | 6 | 0.69(0.60,0.80) | NA | NA | 3 | 0.76(0.49, 1.20) |
Cutoff of staining | ||||||||||||||
1. < 20% | 5 | 0.72(0.38, 1.37) | NA | NA | NA | NA | 6 | 0.59(0.33, 1.06) | 5 | 0.73(0.62, 0.86) | NA | NA | 2 | 0.61(0.16, 2.42) |
2. > = 20% | 2 | 0.71(0.53, 0.93) | NA | NA | NA | NA | 5 | 0.59(0.50, 0.70) | 4 | 0.63(0.52, 0.77) | NA | NA | 4 | 0.63(0.40, 0.98) |
Sample size | ||||||||||||||
<58.5 | 3 | 0.73(0.22, 2.45) | NA | NA | NA | NA | 4 | 0.68(0.39, 1.20) | 5 | 0.68(0.57, 0.81) | 2 | 0.27(0.17, 0.42) | NA | NA |
≥58.5 | 4 | 0.69(0.53, 0.88) | NA | NA | NA | NA | 7 | 0.59(0.44, 0.77) | 4 | 0.69(0.58, 0.82) | 2 | 0.69(0.56, 0.86) | NA | NA |
Follow time(month) | ||||||||||||||
<68.5 | 4 | 0.63(0.47, 0.83) | NA | NA | NA | NA | 5 | 0.68(0.43, 1.07) | 3 | 0.88(0.70, 1.10) | 2 | 0.33(0.04, 2.99) | 2 | 0.93(0.66, 1.29) |
≥68.5 | 2 | 0.68(0.54, 0.85) | NA | NA | NA | NA | 5 | 0.53(0.41, 0.68) | 5 | 0.64(0.54, 0.75) | 2 | 0.45(0.27, 0.76) | 3 | 0.53(0.20, 1.39) |
