Figure 2 | Scientific Reports

Figure 2

From: Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA

Figure 2

Flowchart of HGLDA, demonstrating the basic ideas of predicting potential disease-related lncRNAs by integrating miRNA-disease associations and lncRNA-miRNA interactions.

Firstly, the hypergeometric distribution test was implemented for each lncRNA-disease pair by calculating the P-value to indicate whether this lncRNA and disease significantly shared common miRNAs which can interact with both of them. Then, FDR correction was implemented to all calculated P-values. Finally, those lncRNA-disease pairs with FDR less than 0.05 were selected to be potential lncRNA-disease associations.

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