Figure 3 | Scientific Reports

Figure 3

From: Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA

Figure 3

Flowchart of LFSCM, demonstrating the basic ideas of calculating lncRNA functional similarity based on disease semantic similarity, disease-miRNA associations and lncRNA-miRNA interactions.

Firstly, disease semantic similarity among all the diseases investigated in this paper was calculated based on their disease DAGs. Then, disease set associated with each miRNA was identified and the similarity among these disease sets was calculated and considered to be miRNA functional similarity. Finally, lncRNA functional similarity was calculated based on miRNA functional similarity and lncRNA-miRNA interactions.

Back to article page