Table 2 Correlation of clinicopathological and miR factors with clinical outcome in validation cohort (n = 114).
RFS | Univariate | Multivariable | OS | Univariate | Multivariable | |
|---|---|---|---|---|---|---|
Age (>60 vs ≤ 60) | >60 | HR = 1.02, P = 0.935 | >60 | HR = 1.17, P = 0.590 | ||
95%CI:0.59–1.83 | 95%CI:0.67–2.15 | |||||
Race (AA vs non-AA) | AA | HR = 1.06, P = 0.852 | AA | HR = 1.14, P = 0.692 | ||
95%CI:0.54–1.94 | 95%CI:0.58–2.09 | |||||
Gender (Female vs Male) | Male | HR = 1.20, P = 0.498 | Male | HR = 1.21, P = 0.479 | ||
95%CI:0.71–2.06 | 95%CI:0.71–2.09 | |||||
Smoking history (Yes vs No) | Yes | HR = 1.29, P = 0.344 | Yes | HR = 1.33, P = 0.291 | ||
95%CI:0.76–2.23 | 95%CI:0.78–2.31 | |||||
Alcohol history (Yes vs No) | Yes | HR = 1.77, P = 0.042 | Yes | HR = 1.50, P = 0.141 | ||
95%CI:1.02–3.21 | 95%CI:0.88–2.65 | |||||
Histology (SCC vs ADC) | SCC | HR = 1.61, P = 0.075 | HR = 1.92, | SCC | HR = 1.71, P = 0.048 | HR = 2.16, |
95%CI:0.95–2.72 | P = 0.017 | 95%CI:1.01–2.90 | P = 0.006 | |||
95%CI:1.13–3.26 | 95%CI:1.26–3.72 | |||||
Differentiation (Poor vs Well/Mod) | Poor | HR = 2.71, P = 0.001 | Poor | HR = 2.42, P = 0.042 | ||
95%CI:1.51–4.69 | 95%CI:1.34–4.21 | |||||
TNM stage (II/III/IV vs I) | II–IV | HR = 2.45, P < 0.001 | HR = 2.74, | II–IV | HR = 2.11, P = 0.006 | HR = 2.41, |
95%CI:1.44–4.21 | P < 0.001 | 95%CI:1.24–3.63 | P = 0.002 | |||
95%CI:1.60–4.75 | 95%CI:1.40–4.22 | |||||
miR-21 (High vs Low) | High | HR = 1.65, P = 0.093 | High | HR = 1.61, P = 0.110 | ||
95%CI:0.92–3.14 | 95%CI:0.90–3.07 | |||||
miR-23b (High vs Low) | High | HR = 1.87, P = 0.028 | HR = 2.40, | High | HR = 1.93, P = 0.019 | HR = 2.35, |
95%CI:1.07–3.18 | P = 0.005 | 95%CI:1.12–3.30 | P = 0.005 | |||
95%CI:1.32–4.29 | 95%CI:1.30–4.19 | |||||
miR-31 (High vs Low) | High | HR = 1.22, P = 0.485 | High | HR = 1.70, P = 0.081 | ||
95%CI:0.70–2.21 | 95%CI:0.94–3.29 | |||||
miR-126 (High vs Low) | Low | HR = 1.42, P = 0.203 | Low | HR = 1.31, P = 0.329 | ||
95%CI:0.83–2.52 | 95%CI:0.77–2.31 | |||||
miR-145 (High vs Low) | Low | HR = 1.07, P = 0.844 | Low | HR = 1.02, P = 0.961 | ||
95%CI:0.58–2.11 | 95%CI:0.56–1.97 | |||||
miR-150 (High vs Low) | Low | HR = 1.58, P = 0.104 | HR = 1.92, | Low | HR = 1.49, P = 0.173 | HR = 1.94, |
95%CI:0.91–2.70 | P = 0.034 | 95%CI:0.83–2.56 | P = 0.038 | |||
95%CI:1.05–3.47 | 95%CI:1.04–3.56 | |||||
miR-205 (High vs Low) | High | HR = 1.22, P = 0.459 | High | HR = 1.39, P = 0.228 | ||
95%CI:0.72–2.06 | 95%CI:0.81–2.35 | |||||
miR-296 (High vs Low) | High | HR = 1.13, P = 0.833 | High | HR = 1.22, P = 0.725 | ||
95%CI:0.42–4.65 | 95%CI:0.45–5.03 |
