Figure 3

LIF inhibition during placental development reduces pregnancy viability in mice.

(a) C57BL/6 mice were treated with PEG vehicle control or PEGLA (20 mg/kg/day) from E8–10, E10–13 or E10–17 (n = 4/group) and whole implantation sites collected and counted at E10, 13 or 17 respectively. (b–d) Fetal and placental weights were obtained (grams). (e) A second group of mice treated from E10–17 were left until term and the number of live pups recorded. (f) Pup weights were obtained at D1, 7, 14, 21 post delivery. All data are mean ± SEM, students t-test, *p < 0.05, **p < 0.01.