Figure 5

LIF inhibition during placental development reduces activated STAT3, but not ERK in the mouse placenta.

Representative photomicrographs E10, 13 or 17 implantation sites treated with PEG control or PEGLA from E8–10, E10–13 or E10–17 stained for (a) phosphorylated (p)STAT3 or, (c) pERK1/2. Bar represents 100 μm. Insets are negative controls. (Decidua, D; Junctional Zone, JZ; Labyrinth L). (b,d) The number of positive cells (brown) were counted in at least 4 fields of 3 mid-sagital implantation site sections per mouse (n = 4/group) and averaged. Data are mean ± SEM, students t-test, **p < 0.01, ***p < 0.001.