Figure 6 | Scientific Reports

Figure 6

From: OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation

Figure 6

The effect of OLA1-KD on metastasis in orthotopic breast cancer models.

(A) BLI of female SCID mice bearing MDA-MB-231 (D3H2LN) tumors in their mammary fat pads. Representative images of animals were taken on 30th day after inoculation. Signals from the axillary/brachial regions indicate LN metastasis. The primary tumors were shielded due to their overwhelming brightness. (B) Histologic analysis of the primary tumors, LNs and lungs dissected from the shCTL and shOLA1 groups. The arrows indicate the presence of tumor cells at LN and lung. Bottom: summaries of remote site metastasis as assessed by BLI and histopathology.

Back to article page