Figure 4
Behavioural changes observed following mouse-hippocampal injection of mCRP.
Stereotactic injection of mCRP (50 μg) directly into the CA1 hippocampal region of mice were examined 3–4 weeks after operation. A significant reduction in balance and grip was see in non-transgenic animals in the presence of mCRP (wire hang test; (A) whilst head dipping latency in the Boissier’s hole-board test was significantly increased in 3xTg mice and further increased when mCRP was present (B). In the same test, the latency to entry into 4 holes was significantly increased in both mCRP-treated non-transgenic and 3xTg mice. Statistical analysis was done using two-way ANOVA (*P < 0.05).
