Table 2 Genotypic and allele frequencies of the selected SNPs in p53 pathway genes among patients and controls and the associations of these SNPs with the risk of retinoblastoma.

From: Association of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population

SNPs

Patients (n = 168)

Controls (n = 185)

OR (95% CI)

P a

HWE

n

%

n

%

p a, b

p53 rs1042522

 GG

53

31.5

52

28.1

1.00 (reference)

 

0.053

 GC

81

48.2

104

56.2

0.76 (0.47-1.24)

0.272

 

 CC

34

20.2

29

15.7

1.15 (0.62-2.15)

0.661

 

 C allele

 

44.3

 

43.8

1.02 (0.76-1.38)

0.881

 

MDM2 rs2279744

       

 TT

34

20.2

36

19.6

1.00 (reference)

 

0.715

 TG

75

44.6

88

47.8

0.90 (0.52-1.58)

0.720

 

 GG

59

35.1

60

32.6

1.04 (0.58-1.88)

0.893

 

 T allele

 

42.6

 

43.5

0.96 (0.71-1.30)

0.806

 

p21 rs1801270

       

 CC

51

30.4

46

24.9

1.00 (reference)

 

0.712

 CA

81

48.2

95

51.4

0.77 (0.47-1.26)

0.300

 

 AA

36

21.4

44

23.8

0.74 (0.41-1.34)

0.316

 

 A allele

 

45.5

 

49.5

0.85 (0.64-1.15)

0.297

 
  1. Abbreviations: SNPs, single nucleotide polymorphisms; OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.
  2. aP-value obtained from the Chi-squared test.
  3. bP-value obtained from Hardy-Weinberg equilibrium of the control group.
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