Table 4 Subgroup analyses of the association between the p53 rs1042522 SNP and event-free survival for retinoblastoma invasion.

From: Association of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population

Genotype

Subgroup

Log-rank analysisa

Cox regression modelb

Time to RB invasion (median ± SE, months)

P

HR (95% CI)

P

GG/CC

Lag time ≤1 month

0.5 ± 0.1

 

1.00 (reference)

 

GC

Lag time ≤1 month

5.6 ± 2.4

0.007

0.64 (0.35-1.15)

0.134

GG/CC

Lag time >1 month

5.0 ± 1.0

 

1.00 (reference)

 

GC

Lag time >1 month

8.0 ± 3.5

0.008

0.31 (0.13-0.73)

0.007

GG/CC

No prior treatment

0.5 ± 0.2

 

1.00 (reference)

 

GC

No prior treatment

3.0 ± 0.8

0.004

0.50 (0.30, 0.85)

0.010

GG/CC

Pre-enucleation treatment

13.0 ± 1.0

 

1.00 (reference)

 

GC

Pre-enucleation treatment

18.5 ± 6.0

0.587

0.25 (0.05, 1.14)

0.072

  1. Abbreviations: SNP, single nucleotide polymorphism; SE, standard error.
  2. aCrude analysis.
  3. bThe HRs and P values were adjusted for age, gender, laterality, clinical predictors, ICRB, lag time and pre-enucleation treatment.
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