Figure 1
From: MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1
Increased miR-107 in IBZ promotes angiogenesis in rat after pMCAO.
(A,B) qRT-PCR showed the expression of miR-107 was increased in the IBZ of rats subjected to pMCAO on 3rd and 7th day. *P < 0.05, vs. control group. (C) Capillary density was evaluated by FITC tail vein injection and then the vessel number was quantified by FITC (green). (D) Quantification of capillary density. Data are presented as mean ± SD. Scale bar = 10 μm in D (applies to C). *P < 0.05, vs. antagomir-ctl. (E) qRT-PCR showed the expression of miR-107 after lateral cerebral ventricle injection of antagomir-107 on day 7 after pMCAO. *P < 0.05, vs. antagomir-ctl. (F) Exposure to OGD for 12 h increases miR-107 expression in RBMECs demonstrated by using qRT-PCR. (G) HUVECs. (H) Astrocytes. Data are presented as mean ± SD. *P < 0.05, vs. control group.
