Figure 1
From: Left brain cortical activity modulates stress effects on social behavior
Distinct neuronal firing patterns in the left and right mPFC of stressed mice.
(a) Representative unit firing of left and right mPFC excitatory neurons in non-stressed, susceptible and resilient mice. (b) Comparison of mean firing rates of excitatory neurons between hemispheres. Total unit number/number of mice: non-stressed left, n = 54/6; non-stressed right, n = 21/5; susceptible left, n = 26/5; susceptible right, n = 76/9; resilient left, n = 25/6; resilient right, n = 85/9. Left mPFC mean firing rate in susceptible mice was different from that in non-stressed and resilient mice, whereas the right mPFC firing rate was increased in the resilient group compared with controls. Left mPFC (open bar): F2,14 = 7.355, P = 0.018, one-way ANOVA. Right mPFC (filled bar): F2,20 = 3.368, P = 0.055, one-way ANOVA. Non-stressed Left vs. Susceptible Left, t9 = 3.851, *P = 0.0039, t-test; Susceptible Left vs. Resilient Left, t9 = −3.356, *P = 0.00845, t-test; Non-stressed Left vs. Resilient Left, t10 = −1.039, P = 0.323, t-test; Non-stressed Right vs. Susceptible Right, t12 = −1.560, P = 0.145, t-test; Susceptible Right vs. Resilient Right, P = 0.158, Mann-Whitney Rank Sum test; Non-stressed Right vs. Resilient Right, t12 = −2.914, *P = 0.013, t-test. Data are presented as means ± s.e.m. c, Linear regression analysis showing that social preference indices were positively correlated with left mPFC neuronal activity (left), but not with right mPFC neuronal activity (right). Grey dots, non-stressed mice; red dots, susceptible mice; blue dots, resilient mice. Left mPC: R2 = 0.675, F1,15 = 31.123, P < 0.001, ANOVA. Right mPC: R2 = 0.00305, F1,21 = 0.642, P = 0.802, ANOVA. Data are presented as means ± s.e.m.
