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Figure 1

From: Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease

Figure 1

Macrophage phenotypes signatures construction and gene network representation.

(A) Protocol design for M(IFNγ + LPS, TNFα) and M(IL-4, IL-13) gene signatures. (B) Volcano plots representation of differential expression analyses. Red dots are genes present in all three datasets with adjusted P value ≤0.0001. (C) M(IFNγ + LPS, TNFα) and M(IL-4, IL-13) gene networks (left) and their illustrative topological representation (landscape analysis) showing changes in relative gene expression after IFNγ + LPS or IL-4 stimuli (right) (see Supplementary Table S2 & S3 for the complete list of retrieved genes).

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