Table 1 Gene Set Enrichment Analysis (GSEA) of M(IFNγ + LPS, TNFα) and M(IL-4, IL-13) gene networks in clinical samples.

From: Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease

GEO ID

Cohort Description

Experimental Groups

Reference

GSE40885

Sterile saline was instilled into a lung segment by bronchoscope, followed of instillation of LPS into the contralateral lung for 6 hours. After, a bilateral bronchoalveolar lavage was performed and transcriptional profiling was done on alveolar Mφ.

Alveolar Mφ from saline (n = 7) vs. LPS-treated (n = 7).

Reynier, F. et al. Gene expression profiles in alveolar macrophages induced by lipopolysaccharide in humans. Molecular Medicine 2012 (18):1303–1311.

GSE41649

Transcriptional profiling of bronchial biopsy of healthy and asthmatic subjects.

Healthy (n = 4) vs. asthmatic patients (n = 4).

Chamberland, A. et al. A comparison of two sets of microarray experiments to define allergic asthma expression pattern. Experimental lung research 2009 (35): 399–410.

  1. Abbreviations: IFNγ, interferon-gamma; IL-4, interleukin-4; IL-13, interleukin-13; LPS, lipopolysaccharide; Mφ, macrophages; TNFα, tumor necrosis factor-alpha.
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