Figure 2

Increased proliferative Sox10⁺ glial cells in the injured auditory nerve.

(a–e) A significant increase in BrdU⁺/Sox10⁺ cells (arrows) was seen 7 days after ouabain exposure. 6/8 BrdU⁺/Sox10⁺ cells in (c) also expressed the Sox2 transcription factor (arrows). Mean density of BrdU⁺/Sox10⁺ cells ± S.E.M was obtained from control mice (n = 4) and treated mice at 7 days (n = 6) after ouabain exposure. The percentage of BrdU⁺/Sox10⁺ cells in total BrdU⁺ cells at 7 days after ouabain exposure was plotted in (e). Scale bars, 10 μm in (a) (applies to (a,c)); 10 μm in (c).