Figure 7
Comparison of Sandcastle with ChIPOTle.
ROC-like curves showing the results of Sandcastle peak detection (black lines) compared with ChIPOTle peak detection (green and red lines) in data with background sub-populations simulated with data from normal (a), T- (5 degrees of freedom; (b)) and chi-squared (5 degrees of freedom; (c)) distributions. y-axes show the proportion of true positives correctly identified and x-axes show the proportion of false positive results as a proportion of the number of true positives, such that the best possible results would lie in the top-left corners of the plots. Full calculation details are shown in the Methods section ‘ROC-like curves’. For the normally distributed datasets (a) ChIPOTle was run with options assuming a Gaussian distribution (green lines) and the default option of using a peak height cut-off (red lines). The other distributions (b,c) were run using only the peak height cut-off option (red lines). For all tests it can be seen that Sandcastle outperforms ChIPOTle, as the results lie closer to the top-left corners of the plots.
