Figure 1
From: Histone demethylase JMJD3 is required for osteoblast differentiation in mice
JMJD3 is required for intramembranous ossification in vivo.
(A) The skeletons of E14.5, E16.5, E17.5 and E18.5 wild type and Jmjd3−/− embryos stained with Alizarin S red (bone mineralization) and Alcian blue (cartilage). (B) Skull, parietal bones and clavicles of E18.5 littermates were stained by Alizarin S red and Alcian blue. (C) Quantitative width of the parietal bones in E18.5 WT and Jmjd3−/− embryos. Black arrows: hypoplastic skull and parietal bones of Jmjd3−/− embryos; n = 6. Scale bar: 1 mm.
