Figure 4 | Scientific Reports

Figure 4

From: Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

Figure 4

S1PR2/3 antagonist reduces BMM recruitment in cholestatic liver injury.

(a) Representative confocal images to track the macrophages (F4/80+, red) of BM origin (EGFP+, green) in the BDL-treated livers. DAPI was used to visualize nuclei (blue). Inset: representative images for Sham-treated livers. Scale bars, 50 μm. (b) The proportion of BMMs (numbers of cells with yellow color/red color), was measured by Image-Pro Plus. (c) Flow-cytometric analysis of the non-parenchymal cells (NPC) in the liver for F4/80. (d) The proportion of monocytes/macrophages from BM was measured by FACS Diva 4.1. *P < 0.05 vs. Control. #P < 0.05 vs. BDL group (n = 7 per group).

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