Figure 6 | Scientific Reports

Figure 6

From: Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

Figure 6

S1PR2/3 antagonists attenuate the hepatic fibrosis in cholestatic liver injury.

(a) Representative H&E-staining liver sections after 2-week BDL with JTE-013/CAY-10444 administration. Scale bars, 50 μm. (b) Quantification of necrotic areas. (c) Representative images of Sirius Red staining in the BDL-treated livers with JTE-013/CAY-10444 administration. Scale bars, 50 μm. (d) Quantitative analysis of liver fibrosis. (e) Relative mRNA levels of hepatic α-SMA, Col α1(I), Col α1(III) and TGF-β1. (f) Hydroxyproline content in liver. *P < 0.05 vs. Control. #P < 0.05 vs. BDL group (n = 7 per group).

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